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Uremia
 
Although the term "uremia" literally means the presence of urea (and other nitrogen-containing wastes) in the blood, it is actually the complex terminal stage of kidney failure.

Causes & Development
Uremia can also be caused by NSAIDs, especially in older patients who are being treated primarily with ibuprofen for arthritis.

Signs & Symptoms
Some of the early signs include lethargy, mental depression, loss of appetite, and edema; later symptoms include diarrhea, anemia, convulsions, coma, and a gray-brown coloration.

Treatment & Prevention
Treatment of uremia, which is directed at the underlying kidney disease, is usually with dialysis and renal transplantation.
 
Uremia is linked to:
 
Chronic Renal Insufficiency