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Tripterygium wilfordii Hook F is a plant of the genus Tripterygium of the family celastraceae. Many preparations, mainly from its root, have been used clinically, among which the polyglycoside (TP) has shown better effects. Many side-effects, however, have been reported. In female patients treated with TP, reduction of menses was noted 4 weeks after initiation of therapy, and amenorrhea was observed in 30% and 90% of the cases respectively 3 months after and 6 months after starting use of the extract. Amongst male patients, sperm count and motility was reduced and the sperm disappeared completely after a month.
In general, the longer the duration of administration and the older the patients, the smaller the probability of their menses or sperm returning to normal. [Chin Med J (Taipei) 1996; 57: S35].
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