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| Its fans claim that it alleviates fatigue, fights jet lag, enhances mental clarity, and lifts depression. The most common brand name is "Enada", which is stabilized and enteric-coated, thus preventing stomach acid from destroying the NADH before it enters the bloodstream. Function; Reasons For Use NADH is the body's most potent antioxidant, but any comments on the mechanism of action are speculative. NADH is a redox active substance and participates in biologic energy production. Heart cells, for example, have plenty. Once a cell has less than it needs, everything slows down -- the very definition of aging. And the body doesn't make additional NADH, so to replenish your supply you have to turn to an outside source. Reports that NADH may stimulate endogenous dopamine biosynthesis have led to its experimental use in Parkinson's disease. In one study of 885 subjects with Parkinson's disease, half received oral NADH and half received parenteral NADH with similar results. Some 80% of patients were said to have benefited clinically, with 19.3% showing good improvement, 58.8% moderate improvement and 21.8% not responding. More research is needed to determine the therapeutic role, if any, of NADH in Parkinson's disease. Among the NADH-treated patients, 31% were judged to have notable improvement, while 8% of controls were similarly improved. Results of a FDA-approved study conducted at Georgetown University Medical Center in Washington, DC, indicated that a nutritional supplement called NADH may be a valuable adjunctive therapy in the management of chronic fatigue and immune dysfunction syndrome (CFIDS). These research findings were presented at the November 9, 1997 meeting of the American College of Allergy, Asthma and Immunology in San Diego. This was a blinded, placebo-controlled, 10-week study. More research is warranted to see whether NADH might be useful in cardiovascular disease. Take it on an empty stomach, with at least eight ounces of water. Try this for four months, then take one month off. |
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