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| Since magnesium is mainly an intracellular ion, measurement of serum total magnesium is an inaccurate index of intracellular or total magnesium stores. This means that although your serum levels are being maintained within normal limits, there could be a deficiency in tissues that is not being dectected. Serum Ionized Magnesium. The use of magnesium-specific, ion-selective electrodes to more accurately assess extracellular free magnesium levels is a promising new technology. This technique correlates well with intracellular free magnesium levels in conditions such as diabetes, chronic renal failure and pregnancy. Intracellular free magnesium. Nuclear magnetic resonance (NMR) spectroscopy is the most definitive and noninvasive measure of the active magnesium ion in blood cells or tissues. The lack of routine availability of NMR has limited its clinical use so far. Sublingual magnesium assay. The 'Exatest' is a safe, non-invasive test that accurately measures the minerals inside cells. A doctor painlessly collects a sample from under your tongue and affixes it to a slide. The slide is then sent to IntraCellular Diagnostics, Inc. for analysis. Magnesium Loading Test. This test measures urinary magnesium excretion in response to a loading dose of magnesium. Although inconvenient to perform, this test has successfully identified individuals with even mild degrees of magnesium deficiency. |
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